selegiline.com Report : Visit Site


  • Ranking Alexa Global: # 6,755,154

    Server:Apache...

    The main IP address: 52.44.246.5,Your server United States,Wilmington ISP:E.I. du Pont de Nemours and Co. Inc.  TLD:com CountryCode:US

    The description :from the good drug guide " ..... selegiline , also known as l-deprenyl , is an irreversible and (relatively) selective mao-b inhibitor. meta-analysis of published clinical trials confirms it offers a...

    This report updates in 16-Nov-2018

Created Date:1998-05-12
Changed Date:2018-05-11

Technical data of the selegiline.com


Geo IP provides you such as latitude, longitude and ISP (Internet Service Provider) etc. informations. Our GeoIP service found where is host selegiline.com. Currently, hosted in United States and its service provider is E.I. du Pont de Nemours and Co. Inc. .

Latitude: 39.749801635742
Longitude: -75.554298400879
Country: United States (US)
City: Wilmington
Region: Delaware
ISP: E.I. du Pont de Nemours and Co. Inc.

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HTTP Header Analysis


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Date:Fri, 16 Nov 2018 01:03:37 GMT
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Content-Type:text/html; charset=utf-8
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DNS

soa:ns3.bltc.net. hostmaster.bltc.net. 2007111100 10000 1800 2419200 86400
txt:"v=spf1 -all"
ns:ns3.bltc.net.
ns4.bltc.net.
ipv4:IP:52.44.246.5
ASN:14618
OWNER:AMAZON-AES - Amazon.com, Inc., US
Country:US

HtmlToText

from the good drug guide " ..... selegiline , also known as l-deprenyl , is an irreversible and (relatively) selective mao-b inhibitor. meta-analysis of published clinical trials confirms it offers a cheap, safe and effective symptomatic treatment of early parkinson's disease . selegiline may also be neuroprotective and act as an antidepressant . the enzyme monoamine oxidase has two main forms, type a and type b . they are coded by separate genes. mao may be inhibited with agents that act reversibly or irreversibly; and selectively or unselectively. these categories are not absolute. mao type-a preferentially deaminates serotonin and noradrenaline , and also non-selectively dopamine . type b metabolises dopamine , phenylethylamine (the chocolate amphetamine ) and various trace amines . at dosages up to around 10 mg or so daily, selegiline retains its selectivity for the type-b mao iso-enzyme; but it is also a weak reversible inhibitor of the type-a mao iso-enzyme. in contrast to unselective and irreversible mao inhibitors such as tranylcypromine (parnate) and phenelzine (nardil), both of which strongly potentiate the catecholamine-releasing effect of tyramine , selegiline inhibits it. this ensures that low-dosage selegiline does not induce the hypertensive "cheese effect". a regimen of 2 x 5 mg daily of selegiline irreversibly inhibits over 90% of mao-b in the basal ganglia, the location of over 80% of dopamine in the human brain. this level of mao-b inhibition leads to a 40%-70% increase in synaptic dopamine. selegiline has immune-system -boosting and anti- neurodegenerative effects. its use increases the level of tyrosine hydroxylase , growth hormone , cerebral nitric oxide and the production of key interleukins . selegiline offers protection against dna damage and oxidative stress by hydroxyl and peroxyl radical trapping; and against excitotoxic damage from glutamate . in addition, selegiline stimulates the release of superoxide dismutase (sod). sod is a key enzyme which helps to quench the production of damaging free-radicals . potentially, selegiline may prevent or reverse iron -induced memory impairment. the deposition of excess iron in the brain is implicated several neurodegenerative diseases. selegiline protects the mitochondria via its effects on mitochondrial membrane permeability: it directly interacts with the pore-forming structures. mitochondria are the energy powerhouses of the eukaryotic cell where oxygen respiration occurs. if the mitochondrial theory of aging is correct, then the root cause of aging is damage to mitochondrial dna by free radical leakage from adjacent respiratory proteins. alas selegiline itself is not an elixir of eternal youth. but its current "off-label" use by life-extensionists prefigures the longevity-enhancing mitochondrial medicine of decades to come. taken consistently at low dosage, selegiline tends to extend the life-expectancy of rats by some 20%; enhances drive , libido and endurance; and independently improves cognitive performance in alzheimer's patients and in some healthy normals. its protective role against age-related memory decline derives at least in part from its protection of hippocampal neurons in the aging brain. aging drug-free rats have poorer spatial memories and fewer hippocampal neurons than their counterparts on selegiline. selegiline is already used successfully to treat canine cognitive dysfunction syndrome (cds) in dogs . selegiline retards the metabolism not just of dopamine but also of phenylethylamine , a trace amine also found in chocolate and released when we're in love. selegiline protects the brain's dopamine cells from oxidative stress. the brain has only about 30-40 thousand dopaminergic neurons in all. we tend to lose perhaps 13% a decade in adult life. an eventual 70%-80% loss leads to the dopamine-deficiency disorder parkinson's disease, frequently foreshadowed by depression . selegiline in pill form was approved by the fda as an adjunct in the treatment of parkinson's disease in 1989. in june 2006, the fda approved once-daily orally disintegrating tablets of selegiline hcl branded as zelapar from valeant pharmaceuticals . zelapar is used as an adjunct therapy for parkinsonians on levodopa/carbidopa ( sinemet ) whose response is deteriorating. the cocktail allegedly reduces "off" time by an average of 2.2 hours per day. administered at low doses, selegiline is neuroprotective against possible damage to the serotonergic fine axon terminals caused by overconsumption of the popular drug mdma (ecstasy). several competing theories exist that purport to explain mdma-induced neurotoxicity. one theory blames the deamination by mao-b of excessive dopamine taken up by the membrane-bound transporter into the depleted serotonin terminals. this abnormal uptake follows mdma-induced reversal of the serotonin reuptake pump. in the absence of mao-b inhibition, deamination by mao-b of excess dopamine taken up into the serotonergic axon terminals is liable to generate a glut of toxic free radicals. these highly reactive compounds cause membrane lipid peroxidation and consequent fine terminal degeneration. selegiline prevents such serotonergic damage, in theory at any rate. on the other hand, co-administering un selective selegiline dosages or unselective irreversible maois like tranylcypromine (parnate) or phenelzine (nardil) with mdma is potentially lethal . taken at mao-b-selective dosages, selegiline is typically less effective as a mood-brightener than other dopaminergics such as amineptine (survector) - though occasionally spectacular remission of depressive symptoms may occur even with minimal mao-a inhibition. taken at un selective dosages of 20mg a day or more, selegiline is typically an effective , well-tolerated antidepressant. selegiline at higher dosages may also be useful for " atypical " depressive symptoms of overeating, oversleeping, and hypersensitivity to rejection. an unselective dosage regimen would normally call for an maoi diet (no cheese, red wine, fava beans, salami, etc). however, the gastrointestinal tract can be bypassed. selegiline can be delivered via a one-a-day transdermal patch . in december 2004 , pharmaceutical firms bristol-myers squibb and somerset pharmaceuticals announced they had entered into an agreement to distribute and commercialize emsam - the first transdermal treatment for major depression . better treatment of depression and dysthymia is sorely needed. a february 2008 meta-analysis of (published and unpublished) trials of several commonly prescribed "second generation" antidepressants concluded that they were scarcely more effective than placebos . wrangling over labelling issues delayed emsam's product launch. but in february 2006 , the fda granted emsam a product license for the treatment of major depressive disorder in adults. emsam's pharmacokinetic and pharmacodynamic properties promote the inhibition of mao-a and mao-b in the cns while avoiding significant inhibition of intestinal and liver mao-a enzyme. three different strengths of emsam patch are currently marketed: 20mg/20cm 2 , 30mg/30cm 2 , and 40mg/40cm 2 . the three patch sizes deliver daily doses of selegiline averaging 6mg, 9mg and 12mg respectively. use of the lowest dosage emsam 6 mg/24 hour patch doesn't call for dietary modification. certainly at the lower dosage range, mao-a in the digestive tract is preserved at levels more than adequate to break down tyramine , while mao in the brain is inhibited at levels adequate to induce an antidepressant effect. a restricted "maoi diet" is prudently advised for the higher dosage emsam 9 mg/24 hr patch and the 12 mg/24 hr patch to avoid any risk of hypertensive crisis. but it's worth noting that (as of 2008) no hypertensive crises following dietary indiscretions have been reported even in users of the high strength patches. other prescribing indications for selegiline are in prospect. in november 2004, yale university researchers la

URL analysis for selegiline.com


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Whois Information


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Domain Name: SELEGILINE.COM
Registry Domain ID: 1522697_DOMAIN_COM-VRSN
Registrar WHOIS Server: whois.godaddy.com
Registrar URL: http://www.godaddy.com
Updated Date: 2018-05-11T11:31:08Z
Creation Date: 1998-05-12T04:00:00Z
Registry Expiry Date: 2024-05-11T04:00:00Z
Registrar: GoDaddy.com, LLC
Registrar IANA ID: 146
Registrar Abuse Contact Email: [email protected]
Registrar Abuse Contact Phone: 480-624-2505
Domain Status: clientDeleteProhibited https://icann.org/epp#clientDeleteProhibited
Domain Status: clientRenewProhibited https://icann.org/epp#clientRenewProhibited
Domain Status: clientTransferProhibited https://icann.org/epp#clientTransferProhibited
Domain Status: clientUpdateProhibited https://icann.org/epp#clientUpdateProhibited
Name Server: NS3.BLTC.NET
Name Server: NS4.BLTC.NET
DNSSEC: unsigned
URL of the ICANN Whois Inaccuracy Complaint Form: https://www.icann.org/wicf/
>>> Last update of whois database: 2018-11-16T01:03:27Z <<<

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  REGISTRAR GoDaddy.com, LLC

SERVERS

  SERVER com.whois-servers.net

  ARGS domain =selegiline.com

  PORT 43

  TYPE domain

DOMAIN

  NAME selegiline.com

  CHANGED 2018-05-11

  CREATED 1998-05-12

STATUS
clientDeleteProhibited https://icann.org/epp#clientDeleteProhibited
clientRenewProhibited https://icann.org/epp#clientRenewProhibited
clientTransferProhibited https://icann.org/epp#clientTransferProhibited
clientUpdateProhibited https://icann.org/epp#clientUpdateProhibited

NSERVER

  NS3.BLTC.NET 52.44.246.5

  NS4.BLTC.NET 52.44.246.5

  REGISTERED yes

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